Sodium borohydride → HCID 86714222, compound

Participants

Reaction Steps

Methyl 4-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)-6-chloro-1,5-naphthyridine-3-carboxylate (0.565 g, 1.0 mmol) was added to ethanol (10 mL), to the system added sodium borohydride (0.228 g, 6 mmol) in batches, stirred at room temperature for 18 h. Ethanol was removed under reduced pressure, added 10 mL of water, and extracted with 80 mL of dichloromethane. The organic layer was dried over anhydrous sodium sulfate, concentrated under reduced pressure to give 0.568 g of a crude solid product. The solid was directly used in the next step.

Provenance & Evidence