HCID 90449297, compound → HCID 89589800, compound

Participants

Reaction Steps

tert-butyl 4-((6-chloro-3-(hydroxymethyl)-1,5-naphthyridin-4-yl)amino)piperidine-1-carboxylate (0.39 g, 1 mmol) was dissolved in dichloromethane (10 mL), and to the solution added manganese dioxide (2.14 g, 32 mmol). The reaction mixture was stirred at room temperature for 3 h, filtered and the solid was washed with 30 mL of dichloromethane. The resulting wash liquid and the filtrate were combined and concentrated, and the resulting solid was recrystallized from methanol to give 0.311 g of a white solid.

Provenance & Evidence