Hydrochloric Acid → HCID 90449331, compound

Participants

Reaction Steps

tert-butyl 4-(9-(6-methoxypyridin-3-yl)-3-methyl-2-oxo-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-1(2H)-yl)piperidine-1-carboxylate (75 mg, 0.149 mmol) was dissolved in dichloromethane (10 mL), hydrogen chloride gas was blown to the system for 0.5 h, and a solid was precipitated. The reaction mixture was filtered, the filter cake was washed sequentially with dichloromethane and diethyl ether, and the resulting solid was dried to give 50 mg of the titled compound.

Provenance & Evidence