Cyclohexene → 1-propyl-8-(1H-pyrazol-4-yl)-1,7-dihydro-purin-6-one

HRID 925533Notes

Reaction equation

HRID 925533 reaction equation
C([N:8]1[CH:12]=[C:11]([C:13]2[N:21](COCC[Si](C)(C)C)[C:20]3[C:19](=[O:30])[N:18]([CH2:31][CH2:32][CH3:33])[C:17](Cl)=[N:16][C:15]=3[N:14]=2)[CH:10]=[N:9]1)C1C=CC=CC=1.C1CCCCC=1>C(O)C>[CH2:31]([N:18]1[C:19](=[O:30])[C:20]2[NH:21][C:13]([C:11]3[CH:12]=[N:8][NH:9][CH:10]=3)=[N:14][C:15]=2[N:16]=[CH:17]1)[CH2:32][CH3:33]

Participants

4

Reactant 2

HCID 8079CyclohexeneHCID 671348358-(1-Benzyl-1H-pyrazol-4-yl)-2-chloro-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

Product 1

HCID 469129841-propyl-8-(1H-pyrazol-4-yl)-1,7-dihydro-purin-6-oneYield 36.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 8-(1-Benzyl-1H-pyrazol-4-yl)-2-chloro-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one (0.1 g, 0.201 mmol), Pd (OH)2 (20%) (0.2 g), in ethanol (4 ml) and cyclohexene were stirred under nitrogen balloon for 25 hrs. Reaction mixture was filtered through celite bed washed with methanol (20 ml). The filtrate was concentrated under vacuum and the crude product was purified by column chromatography using silica gel (100-200 mesh) and 5 to 6% methanol in DCM as an eluent to obtain 1-propyl-8-(1H-pyrazol-4-yl)-1,7-dihydro-purin-6-one (0.018 g, 24%) as white solid.

Workup

  1. customReaction mixture
  2. filtrationwas filtered through celite bed
  3. washwashed with methanol (20 ml)
  4. concentrationThe filtrate was concentrated under vacuum
  5. customthe crude product was purified by column chromatography

Sources & evidence

ORD record
ord-338b9d037ef54c668c957edf3a946717
Source dataset
uspto-grants-2016_03
Patent number
US09284316B2

Reaction notes

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