HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → Methyl alpha-(2,6-diallyl-4-hydroxyphenoxy)4-chlorobenzeneacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methyl 2-bromo-2-(4-chlorophenyl)acetate | HCID 10777987 | — |
| Reactant | 2,6-Diallyl4-benzyloxyphenol | HCID 21985951 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl alpha-(2,6-diallyl-4-hydroxyphenoxy)4-chlorobenzeneacetate | HCID 21985939 | — |
Reaction Steps
To a solution of 2,6-diallyl-4-benzyloxyphenol (200 mg, 1.0 eq) in DMF (8 mL) were added methyl α-bromo-4-chlorobenzeneacetate (190 mg, 1.0 eq) and Cs2CO3 (285 mg, 1.2 eq). The reaction mixture was stirred at room temperature for 15 h, poured into ether, washed with water and brine, dried over MgSO4, filtered, and concentrated in vac. Purification by chromatography (SiO2, EtOAc/Hexanes 1:20) afforded the desired methyl α-(2,6-diallyl-4-hydroxyphenoxy)-4-chlorobenzeneacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07091230B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-cbe90fa9d62e4ab79ebe977953f20624 |
| Source note | uspto-grants-2006_08 |