Diisopropylethylamine → {(2S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]pyrrolidin-2-yl}methanol

Participants

Reaction Conditions

Reaction Steps

To a mixture of 40.5 mg (0.15 mmol) 3-(1-benzofur-2-yl)-6-chloroimidazo[1,2-b]pyridazine and 25 mg (0.195 mmol) diisopropylethylamine in 1 mL of 1-butanol were added 21 mg (0.22 mmol) (2S)-pyrrolidin-2-ylmethanol in 0.3 mL NMP. The mixture is stirred at 120° C. for 8 h. 16 mg (0.16 mmol) (2S)-pyrrolidin-2-ylmethanol in 0.2 mL NMP were added and shaking at 120° C. was continued for 8 h. Again, 16 mg (0.16 mmol) (2S)-pyrrolidin-2-ylmethanol in 0.2 mL NMP were added and shaking at 120° C. was continued for 8 h.

Provenance & Evidence