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HRID925607

反应详情

EQUATION

反应方程式

HRID 925607 的结构方程式

REACTANTS

反应物

2
结构：O[C@@H]1CCNC1
HCID2759337

(R)-3-Hydroxypyrrolidine

C4H9NO

结构：Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1
HCID71491928

未命名化合物

PRODUCTS

生成物

1
结构：O[C@@H]1CCN(c2ccc3ncc(-c4cc5ccccc5o4)n3n2)C1
HCID71145051

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCO
溶剂HCID263

1-Butanol

C4H10O

PROCEDURE

实验过程

150 mg (0.56 mmol) 3-(1-benzofur-2-yl)-6-chloroimidazo[1,2-b]pyridazine and 206.2 mg (1.67 mmol) (3R)-pyrrolidin-3-ol in 5.0 mL butan-1-ol were stirred 72 h at 150° C. The solvent was removed. The residue was purified by HPLC to yield 23 mg (13%).

WORKUP

后处理

  1. customThe solvent was removed
  2. customThe residue was purified by HPLC
  3. customto yield 23 mg (13%)