trans-N,N'-dimethyl-1,2-cyclohexanediamine → HCID 71042406, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-[(6-chloropyridin-3-yl)methyl]-3-[(1S,2S)-2-hydroxycyclohexyl]-10-methyl-9,10-dihydropyrido[3,2-h]quinazolin-4(3H)-one (Example 1, 0.050 g, 0.11 mmol) in 1 mL of methanol under an atmosphere of nitrogen was added trans-N,N′-dimethylcyclohexane-1,2-diamine (1.6 mg, 0.011 mmol) and copper(I) iodide (2.2 mg, 0.011 mmol). The mixture was heated at 160° C. for 2 h in a sealed pressure vessel, cooled to rt, and concentrated in vacuo. The residue was purified via preparative reverse phase HPLC to provide the title compounds.

Provenance & Evidence