反应详情

温度

60 °C

To an ethanol (8 mL) solution of methyl 1-{4-[(1-cyclobutylpiperidin-4-yl)oxy]phenyl}-1H-pyrrole-3-carboxylate (1.4 g) synthesized in Example 1, 6 N aqueous sodium hydroxide solution (1.32 mL) was added and the mixture was stirred at 60° C. for 4 hours. The reaction mixture was left to cool to room temperature and, after adding water, extracted with chloroform. The aqueous layer was neutralized with hydrochloric acid and extracted with chloroform. The combined organic layer was dried over magnesium sulfate and concentrated under reduced pressure to give the titled compound as a colorless amorphous substance (1.22 g).

1. waitThe reaction mixture was left
2. temperatureto cool to room temperature
3. extractionextracted with chloroform
4. extractionextracted with chloroform
5. dry with materialThe combined organic layer was dried over magnesium sulfate
6. concentrationconcentrated under reduced pressure