Pyrrolidine → HCID 71599104, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the methyl 1-{4-[(1-cyclobutylpiperidin-4-yl)oxy]phenyl}-2,5-dimethyl-1H-pyrrole-3-carboxylate (0.06 g) synthesized in Example 4 and pyrrolidine (0.112 g) was stirred in a sealed tube at 100° C. for 16 hours. The reaction mixture was left to cool to room temperature and concentrated under reduced pressure; the resulting residue was purified by silica gel column chromatography (NH preparative silica gel plate 0.5 mm; eluent: n-hexane/ethyl acetate=50/50) to give the titled compound as a colorless solid.

Provenance & Evidence