Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-methyl-1H-pyrrole-3-carboxylic acid → [1-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-1H-pyrrol-3-yl](pyrrolidin-1-yl)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-methyl-1H-pyrrole-3-carboxylic acid | HCID 10154054 | — |
| 반응물 | 3-(pyrrolidin-1-ylcarbonyl)-1H-pyrrole | HCID 15851739 | — |
| 반응물 | (2R)-1-[3-(4-iodophenoxy)propyl]-2-methylpyrrolidine | HCID 57675747 | — |
| 반응물 | 1-Cyclobutyl-4-(4-iodophenoxy)piperidine | HCID 67548608 | — |
| 생성물 | [1-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-1H-pyrrol-3-yl](pyrrolidin-1-yl)methanone | HCID 117640920 | — |
반응 단계
The titled compound was prepared as a colorless amorphous substance by repeating the procedure of Example 1, except that the 1-cyclobutyl-4-(4-iodophenoxy)piperidine was replaced by (2R)-1-[3-(4-iodophenoxy)propyl]-2-methylpyrrolidine (which can be synthesized in accordance with the method described in WO2009063953) and the methyl 1H-pyrrole-3-carboxylic acid by 3-(pyrrolidin-1-ylcarbonyl)-1H-pyrrole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09284324B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-0dc2bfb247904b69b401d99b5c5642dc |
| 출처 메모 | uspto-grants-2016_03 |