1-methyl-1H-pyrrole-3-carboxylic acid → HCID 71576830, compound

HRID 925631Notes

Reaction equation

HRID 925631 reaction equation
CN1C=CC(C(O)=O)=C1.[NH:10]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:16])=[CH:11]1.[CH:22]1([N:26]2[CH2:31][CH2:30][CH:29]([O:32][C:33]3[CH:38]=[CH:37][C:36](I)=[CH:35][CH:34]=3)[CH2:28][CH2:27]2)[CH2:25]C[CH2:23]1.IC1C=CC(OC2CCN(C(C)C)CC2)=CC=1>>[CH:22]([N:26]1[CH2:31][CH2:30][CH:29]([O:32][C:33]2[CH:34]=[CH:35][C:36]([N:10]3[CH:14]=[CH:13][C:12]([C:15]([N:17]4[CH2:21][CH2:20][CH2:19][CH2:18]4)=[O:16])=[CH:11]3)=[CH:37][CH:38]=2)[CH2:28][CH2:27]1)([CH3:25])[CH3:23]

Participants

5

Reactant 4

HCID 101540541-methyl-1H-pyrrole-3-carboxylic acidHCID 158517393-(pyrrolidin-1-ylcarbonyl)-1H-pyrroleHCID 675486081-Cyclobutyl-4-(4-iodophenoxy)piperidineHCID 685907414-(4-Iodophenoxy)-1-(1-methylethyl)piperidine

Product 1

HCID 71576830HCID 71576830, compound

Procedure

The titled compound was prepared as a colorless amorphous substance by repeating the procedure of Example 1, except that the methyl 1H-pyrrole-3-carboxylic acid was replaced by (1H-pyrrol-3-yl)(pyrrolidin-1-yl)methanone and the 1-cyclobutyl-4-(4-iodophenoxy)piperidine by 4-(4-iodophenoxy)-1-isopropylpiperidine (which can be synthesized in accordance with the method described in WO2004089373).

Sources & evidence

ORD record
ord-b5fad3ebb26f422eb8d32ae11ff2b920
Source dataset
uspto-grants-2016_03
Patent number
US09284324B2

Reaction notes

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