1-methyl-1H-pyrrole-3-carboxylic acid → HCID 71599106, compound

HRID 925632Notes

Reaction equation

HRID 925632 reaction equation
CN1C=CC(C(O)=O)=C1.[CH3:10][NH:11][C:12]([C:14]1[CH:18]=[CH:17][NH:16][CH:15]=1)=[O:13].[CH:19]1([N:23]2[CH2:28][CH2:27][CH:26]([O:29][C:30]3[CH:35]=[CH:34][C:33](I)=[CH:32][CH:31]=3)[CH2:25][CH2:24]2)[CH2:22]C[CH2:20]1.IC1C=CC(OC2CCN(C(C)C)CC2)=CC=1>>[CH:19]([N:23]1[CH2:28][CH2:27][CH:26]([O:29][C:30]2[CH:31]=[CH:32][C:33]([N:16]3[CH:17]=[CH:18][C:14]([C:12]([NH:11][CH3:10])=[O:13])=[CH:15]3)=[CH:34][CH:35]=2)[CH2:25][CH2:24]1)([CH3:22])[CH3:20]

Participants

5

Reactant 4

HCID 101540541-methyl-1H-pyrrole-3-carboxylic acidHCID 55284998N-methyl-1H-pyrrole-3-carboxamideHCID 675486081-Cyclobutyl-4-(4-iodophenoxy)piperidineHCID 685907414-(4-Iodophenoxy)-1-(1-methylethyl)piperidine

Product 1

HCID 71599106HCID 71599106, compound

Procedure

The titled compound was prepared as a colorless crystal by repeating the procedure of Example 1, except that the methyl 1H-pyrrole-3-carboxylic acid was replaced by N-methyl-1H-pyrrole-3-carboxamide and the 1-cyclobutyl-4-(4-iodophenoxy)piperidine by 4-(4-iodophenoxy)-1-isopropylpiperidine.

Sources & evidence

ORD record
ord-10055ea2e64746fe8d89fd10eb7ef2a4
Source dataset
uspto-grants-2016_03
Patent number
US09284324B2

Reaction notes

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