HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-1H-pyrrole-3-carboxylic acid → (1-{4-[(1-tert-butylpiperidin-4-yl)oxy]phenyl}-1H-pyrrol-3-yl)(pyrrolidin-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-1H-pyrrole-3-carboxylic acid | HCID 10154054 | — |
| Reactant | 3-(pyrrolidin-1-ylcarbonyl)-1H-pyrrole | HCID 15851739 | — |
| Reactant | 1-Cyclobutyl-4-(4-iodophenoxy)piperidine | HCID 67548608 | — |
| Reactant | 1-Tert-butyl-4-(4-iodophenoxy)piperidine | HCID 68591489 | — |
| Product | (1-{4-[(1-tert-butylpiperidin-4-yl)oxy]phenyl}-1H-pyrrol-3-yl)(pyrrolidin-1-yl)methanone | HCID 117640892 | — |
Reaction Steps
The titled compound was prepared as a colorless crystal by repeating the procedure of Example 1, except that the methyl 1H-pyrrole-3-carboxylic acid was replaced by (1H-pyrrol-3-yl)(pyrrolidin-1-yl)methanone and the 1-cyclobutyl-4-(4-iodophenoxy)piperidine by 1-tert-butyl-4-(4-iodophenoxy)piperidine (which can be synthesized in accordance with the method described in WO2008072724).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284324B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-f47383d002cb4fba84251b0680d7a8a1 |
| Source note | uspto-grants-2016_03 |