1-methyl-1H-pyrrole-3-carboxylic acid → 1-{4-[(1-tert-butylpiperidin-4-yl)oxy]phenyl}-N-methyl-1H-pyrrole-3-carboxamide

HRID 925634Notes

Reaction equation

HRID 925634 reaction equation
CN1C=CC(C(O)=O)=C1.[CH3:10][NH:11][C:12]([C:14]1[CH:18]=[CH:17][NH:16][CH:15]=1)=[O:13].C1(N2CCC(OC3C=CC(I)=CC=3)CC2)CCC1.[C:37]([N:41]1[CH2:46][CH2:45][CH:44]([O:47][C:48]2[CH:53]=[CH:52][C:51](I)=[CH:50][CH:49]=2)[CH2:43][CH2:42]1)([CH3:40])([CH3:39])[CH3:38]>>[C:37]([N:41]1[CH2:42][CH2:43][CH:44]([O:47][C:48]2[CH:53]=[CH:52][C:51]([N:16]3[CH:17]=[CH:18][C:14]([C:12]([NH:11][CH3:10])=[O:13])=[CH:15]3)=[CH:50][CH:49]=2)[CH2:45][CH2:46]1)([CH3:40])([CH3:38])[CH3:39]

Participants

5

Reactant 4

HCID 101540541-methyl-1H-pyrrole-3-carboxylic acidHCID 55284998N-methyl-1H-pyrrole-3-carboxamideHCID 675486081-Cyclobutyl-4-(4-iodophenoxy)piperidineHCID 685914891-Tert-butyl-4-(4-iodophenoxy)piperidine

Product 1

HCID 715991011-{4-[(1-tert-butylpiperidin-4-yl)oxy]phenyl}-N-methyl-1H-pyrrole-3-carboxamide

Procedure

The titled compound was prepared as a colorless crystal by repeating the procedure of Example 1, except that the methyl 1H-pyrrole-3-carboxylic acid was replaced by N-methyl-1H-pyrrole-3-carboxamide and the 1-cyclobutyl-4-(4-iodophenoxy)piperidine by 1-tert-butyl-4-(4-iodophenoxy)piperidine.

Sources & evidence

ORD record
ord-7062e85d4d3b49d4b485b7b305074e44
Source dataset
uspto-grants-2016_03
Patent number
US09284324B2

Reaction notes

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