HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Methoxyphenyl)boronic acid → 8-Fluoro-6-(4-methoxy-phenyl)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Methoxyphenyl)boronic acid | HCID 201262 | — |
| Reactant | 6-Bromo-8-fluoro-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one | HCID 90036902 | — |
| Product | 8-Fluoro-6-(4-methoxy-phenyl)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one | HCID 90036587 | — |
Reaction Steps
The title compound, white solid (33 mg, 43%), MS (ISP) m/z=311.3 [(M+H)+], mp 274.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-fluoro-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 1) (70.8 mg, 0.25 mmol) and commercially available 4-methoxy-phenylboronic acid (49.4 mg, 0.325 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284321B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-d6f840fc126847a382a63491d9f59b54 |
| Source note | uspto-grants-2016_03 |