HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Pyridin-4-yl)boronic acid → 8-Fluoro-6-pyridin-4-yl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| Reactant | 6-Bromo-8-fluoro-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one | HCID 90036902 | — |
| Product | 8-Fluoro-6-pyridin-4-yl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one | HCID 73335516 | — |
Reaction Steps
The title compound, white solid (44 mg, 63%), MS (ISP) m/z=282.3 [(M+H)+], mp 323.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-fluoro-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 1) (70.8 mg, 0.25 mmol) and commercially available pyridine-4-ylboronic acid (39.9 mg, 0.325 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284321B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-3ec1c0b44c3a4e4f851554c2ea325977 |
| Source note | uspto-grants-2016_03 |