3,4-Difluorobenzeneboronic acid → HCID 90036898, compound

Participants

Reaction Steps

The title compound, white solid (69 mg, 80%), MS (ISP) m/z=347.4 [(M+H)+], mp 235.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-chloro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 12) (78.4 mg, 0.25 mmol) and commercially available 3,4-difluoro-phenylboronic acid (51.3 mg, 0.325 mmol).

Provenance & Evidence