3,4-Difluorobenzeneboronic acid → HCID 73335109, compound

Participants

Reaction Steps

The title compound, light grey solid (71 mg, 86%), MS (ISP) m/z=331.4 [(M+H)+], mp 229.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 14) (74.3 mg, 0.25 mmol) and commercially available 3,4-difluoro-phenylboronic acid (51.3 mg, 0.325 mmol).

Provenance & Evidence