3,4-Difluorobenzeneboronic acid → HCID 90036005, compound

Participants

Reaction Steps

The title compound, off-white solid (68 mg, 84%), MS (ISP) m/z=324.4 [(M+H)+], mp 289.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-1-oxo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole-8-carbonitrile (intermediate 15) (72.5 mg, 0.25 mmol) and commercially available 3,4-difluoro-phenylboronic acid (51.3 mg, 0.325 mmol).

Provenance & Evidence