(4-Chloro-2-fluorophenyl)boronic acid → HCID 118341149, compound

Participants

Reaction Steps

The title compound, white solid (55 mg, 61%), MS (ISP) m/z=363.4 [(M+H)+], mp 251.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-chloro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 12) (78.4 mg, 0.25 mmol) and commercially available 4-chloro-2-fluoro-phenylboronic acid (56.7 mg, 0.325 mmol).

Provenance & Evidence