2-Fluoropyridine-4-boronic acid → HCID 118341130, compound

Participants

Reaction Steps

The title compound, off-white solid (67 mg, 81%), MS (ISP) m/z=330.5 [(M+H)+], mp 290.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-chloro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 12) (78.4 mg, 0.25 mmol) and commercially available 2-fluoro-pyridin-4-ylboronic acid (45.8 mg, 0.325 mmol).

Provenance & Evidence