4-(Hydroxymethyl)benzeneboronic acid → HCID 90036274, compound

Participants

Reaction Steps

The title compound, off-white solid (78 mg, 92%), MS (ISP) m/z=341.5 [(M+H)+], mp 211° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-chloro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 12) (78.4 mg, 0.25 mmol) and commercially available 4-hydroxymethyl-phenylboronic acid (49.4 mg, 0.325 mmol).

Provenance & Evidence