4-(Hydroxymethyl)benzeneboronic acid → HCID 73335311, compound

Participants

Reaction Steps

The title compound, white solid (59 mg, 73%), MS (ISP) m/z=325.5 [(M+H)+], mp 220° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 14) (74.3 mg, 0.25 mmol) and commercially available 4-hydroxymethyl-phenylboronic acid (49.4 mg, 0.325 mmol).

Provenance & Evidence