(4-Fluoro-3-methylphenyl)boronic acid → HCID 118341161, compound

Participants

Reaction Steps

The title compound, off-white solid (73 mg, 85%), MS (ISP) m/z=343.5 [(M+H)+], mp 235.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-chloro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 12) (78.4 mg, 0.25 mmol) and commercially available 4-fluoro-3-methyl-phenylboronic acid (50.0 mg, 0.325 mmol).

Provenance & Evidence