4-(Trifluoromethoxy)phenylboronic acid → HCID 118341134, compound

Participants

Reaction Steps

The title compound, white solid (84 mg, 87%), MS (ISP) m/z=386.4 [(M+H)+], mp 239° C., was prepared in accordance with the general method of example 1 from 6-bromo-10-methyl-1-oxo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole-8-carbonitrile (intermediate 16) (76 mg, 0.25 mmol) and commercially available 4-trifluoromethoxy-phenylboronic acid (66.9 mg, 0.325 mmol).

Provenance & Evidence