(4-Chloro-2-fluorophenyl)boronic acid → HCID 90036201, compound

Participants

Reaction Steps

The title compound, light brown solid (65 mg, 77%), MS (ISP) m/z=340.3 [(M+H)+], mp 278° C., was prepared in accordance with the general method of example 1 from 6-bromo-1-oxo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole-8-carbonitrile (intermediate 15) (72.5 mg, 0.25 mmol) and commercially available 4-chloro-2-fluoro-phenylboronic acid (56.7 mg, 0.325 mmol).

Provenance & Evidence