(4-Chloro-2-fluorophenyl)boronic acid → HCID 90035977, compound

Participants

Reaction Steps

The title compound, off-white solid (66 mg, 75%), MS (ISP) m/z=354.5 [(M+H)+], mp 270° C., was prepared in accordance with the general method of example 1 from 6-bromo-10-methyl-1-oxo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole-8-carbonitrile (intermediate 16) (76 mg, 0.25 mmol) and commercially available 4-chloro-2-fluoro-phenylboronic acid (56.7 mg, 0.325 mmol).

Provenance & Evidence