4-(Trifluoromethyl)phenylboronic acid → HCID 90036737, compound

Participants

Reaction Steps

The title compound, white solid (74 mg, 77%), MS (ISP) m/z=384.6 [(M+H)+], mp 252° C., was prepared in accordance with the general method of example 1 from 7-bromo-11-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-9-carbonitrile (intermediate 17) (79.5 mg, 0.25 mmol) and commercially available 4-trifluoromethyl-phenylboronic acid (61.7 mg, 0.325 mmol).

Provenance & Evidence