4-(Trifluoromethyl)phenylboronic acid → HCID 90036456, compound

Participants

Reaction Steps

The title compound, white solid (87 mg, 84%), MS (ISP) m/z=415.4 [(M+H)+], mp 243° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-(trifluoromethoxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 19) (87.3 mg, 0.25 mmol) and commercially available 4-trifluoromethyl-phenylboronic acid (61.7 mg, 0.325 mmol).

Provenance & Evidence