4-Chloro-3-fluorophenylboronic Acid → 7-(4-Chloro-3-fluorophenyl)-11-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-9-carbonitrile

Participants

Reaction Steps

The title compound, off-white solid (85 mg, 92%), MS (ISP) m/z=368.4 [(M+H)+], mp 247.5° C., was prepared in accordance with the general method of example 1 from 7-bromo-11-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-9-carbonitrile (intermediate 17) (79.5 mg, 0.25 mmol) and commercially available 4-chloro-3-fluoro-phenylboronic acid (56.7 mg, 0.325 mmol).

Provenance & Evidence