反应详情

2-(4-Isopropylthiazol-2-yl)-5,7-dimethoxyquinolin-4-ol 218e was synthesized from compound 217e as a yellow solid in 60% yield, according to the procedures as described for compound 218a. 1H NMR (CDCl3, 400 MHz) δ (ppm) 1.37 (s, 3H), 1.39 (s, 3H), 3.15-3.22 (m, 1H), 3.95 (s, 3H), 4.05 (s, 3H), 6.45 (s, 1H), 7.03 (s, 2H), 7.62 (brs, 1H), 9.55 (s, 1H); MS (ESI, EI+): m/z=331(MH+).