HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 2,4-Dichloro-7-methoxy-8-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 2,4,8-Trichloro-7-methoxyquinoline | HCID 2794516 | — |
| Reactant | 3-Methoxy-2-methylaniline hydrochloride | HCID 52911138 | — |
| Product | 2,4-Dichloro-7-methoxy-8-methylquinoline | HCID 53400954 | 43% |
Reaction Steps
2,4-Dichloro-8-methyl-7-methoxyquinoline 220b was synthesized from 2-methyl-3-methoxyaniline hydrochloride 215b and malonic acid as a white powder in 43% yield, following the procedure as described for compound 220d. 1H NMR (CDCl3, 376 MHz) δ (ppm) 2.62 (s, 3H), 4.03 (s, 3H), 7.34 (s, 1H), 7.37 (d, J=9.02 Hz, 1H), 8.05 (d, J=9.02 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284307B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-540bc67ef3a74b0d9334699ad1bd513c |
| Source note | uspto-grants-2016_03 |