Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Boron Trichloride | HCID 25135 | — |
| Reactant | 4,6-Dimethoxy-2-(4-trifluoromethyl-thiazol-2-yl)-pyrimidin-4-ol | HCID 178493596 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 178494417 | HCID 178494417 | 38% |
Reaction Steps
To a solution of compound 288 (460 mg, 1 eq.) in DCE (10 mL) was added BCl3 (3.16 mL, 2 eq.). The mixture was stirred at 60° C. for 16 hrs. Water and DCM were then added. Organics were separated, dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was triturated in a DCM/pentane mixture to yield compound 289 as a beige solid in 38% yield. MS (ESI, EI+): m/z=278 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09284307B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-65e6bdd500a8446f8b4742946d6372e1 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
