Hydrogen Bromide → 2-Amino-6-benzothiazolol

Participants

Reaction Steps

2-Amino-6-methoxybenzothiazole was reacted with hot aqueous HBr at a temperature of >70° C. for about 3 hours and then the clear solution was cooled to ambient temperature overnight. The precipitated solids were collected, dissolved in hot water and the pH was adjusted to between 4.5-5.5. The resultant solids were collected, dried and re-crystallized from isopropanol. Second crop material was collected. The solids were vacuum dried to give 2-amino-6-hydroxybenzothiazole.

Provenance & Evidence