HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 71238765, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 68207886 | HCID 68207886 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 71238765 | HCID 71238765 | 97.8% |
Reaction Steps
To a mixture of 43.9 g of methyl 4-[2-(4-aminophenyl)ethyl]benzoate, 22.3 g of cyanoacetic acid, and 150 mL of DMF was added 49.5 g of EDCI/hydrochloride under ice-cooling. After stirring at room temperature for 24 hours, to the reaction mixture was added 450 mL of water at room temperature. After vigorous stirring at room temperature for 30 minutes, the precipitate was collected by filtration to obtain 54.2 g of methyl 4-(2-{4-[(cyanoacetyl)amino]phenyl}ethyl)benzoate as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284295B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-93266d7520104b6f8866572697822072 |
| Source note | uspto-grants-2016_03 |