HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 71238730, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Benzoic acid, 4-[3-(4-aminophenyl)propyl]-, methyl ester | HCID 68207867 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 71238730 | HCID 71238730 | 96.6% |
Reaction Steps
To a mixture of 16.0 g of methyl 4-[3-(4-aminophenyl)propyl]benzoate, 7.70 g of cyanoacetic acid, and 50 mL of DMF was added 17.1 g of EDCI/hydrochloride under ice-cooling. After stirring at room temperature for 18 hours, to the reaction mixture was added 200 mL of water at room temperature. After vigorous stirring at room temperature for 30 minutes, the precipitate was collected by filtration to obtain 19.3 g of methyl 4-(3-{4-[(cyanoacetyl)amino]phenyl}propyl)benzoate as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284295B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-bdf61bc35942492f983b9f092e0cc77c |
| Source note | uspto-grants-2016_03 |