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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 92608Generated: October 28, 2026

Acetamide → 4-(5-Acetylamino-3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid benzyl ester

https://huagongshe.com/reaction/92608

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetamideHCID 178—
ReactantChloroformHCID 6212—
ReactantCarbonate IonHCID 19660—
ReactantPalladiumHCID 23938—
Reactant1,4-DioxaneHCID 31275—
ReactantDibenzylidene acetoneHCID 95417—
ReactantCesium cationHCID 104967—
Reactant1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 636044—
Reactant4-(5-Bromo-3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid benzyl esterHCID 67400639—
Product4-(5-Acetylamino-3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid benzyl esterHCID 67400940—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
ORD IDord-13a0036c2fe14bd1a38cedd58036c71d
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (2/10)