Hydrochloric Acid → HCID 86705389, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 6-(4-methoxybenzyl)-9-((methoxymethoxy)methyl)pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one (Example 31, 40 mg, 0.10 mmol), methanol (0.80 mL) and 5 N hydrochloric acid (0.40 mL) was stirred at 50° C. for 16 h. The mixture was extracted with DCM (1 mL), basified to pH 14 with 15% aqueous sodium hydroxide and extracted with DCM (2 mL). The combined DCM extracts were concentrated under reduced pressure. Purification (HPLC, 10-90% ACN-water) afforded the title compound (21 mg, 59%) as a white powder. 1H NMR (400 MHz, DMSO-d6) δ 3.69 (s, 3H), 4.69 (d, J=4.6 Hz, 2H), 5.54 (t, J=4.6 Hz, 1H), 5.59 (s, 2H), 6.84 (d, J=6.9 Hz, 2H), 7.36 (d, J=6.9 Hz, 2H), 8.58 (d, J=1.6 Hz, 1H), 8.60 (s, 1H), 8.72 (d, J=1.6 Hz, 1H). [M+H]=338.1.

Provenance & Evidence