Hydrochloric Acid → HCID 86705392, compound

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Reaction Steps

8-(Dimethoxymethyl)-6-(4-methoxybenzyl)pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one (Example 3, 682 mg, 1.79 mmol), THF (20 mL), water (5 mL) and 12 N hydrochloric acid (3 mL) were combined and stirred at room temperature for 20 h. The mixture was neutralized slowly with powdered sodium bicarbonate to pH 8. The mixture was diluted with water (20 mL) and extracted with EtOAc (3×20 mL). The combined extracts were dried (MgSO4) and concentrated to afford the title compound (516 mg, 77%) as a yellow foam, which was used without further purification. 1H NMR (400 MHz, CDCl3) δ 3.73-3.81 (m, 3H), 5.83, (s, 2H), 6.85 (d, J=8.66 Hz, 2H), 7.64 (d, J=8.53 Hz, 2H), 8.03 (d, J=7.78 Hz, 1H), 8.42 (s, 1H), 8.83 (d, J=7.91 Hz, 1H), 10.22 (s, 1H). [M+H]=336.1.

Provenance & Evidence