Hydrochloric Acid → HCID 86705394, compound

Participants

Reaction Steps

9-(1-Ethoxyvinyl)-6-(4-methoxybenzyl)pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one (Example 32, 147 mg, 0.39 mmol) was suspended in dioxane (6 mL) and 6 N hydrochloric acid (3 mL) and stirred for 4 h. The mixture was basified to pH 11 with 1 N sodium hydroxide and extracted with DCM (3×15 mL). The combined extracts were dried (MgSO4) and concentrated to afford 122 mg (90%) of the title compound as a yellow solid. 1H NMR (400 MHz, CDCl3) δ 2.73 (s, 3H), 3.76 (s, 3H), 5.79 (s, 2H), 6.78-6.89 (m, 2H), 7.56-7.66 (m, 2H), 8.39 (s, 1H), 9.13 (d, J=2.26 Hz, 1H), 9.35 (d, J=2.26 Hz, 1H). [M+H]=350.2.

Provenance & Evidence