Methanesulfonyl chloride → HCID 72706382, compound

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Reaction Steps

2,2,2-Trifluoro-1-(6-(4-methoxybenzyl)-5-oxo-5,6-dihydropyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-9-yl)ethyl methanesulfonate. Methane sulfonyl chloride (49 μl, 0.63 mmol) was added to a stirred solution of 6-(4-methoxybenzyl)-9-(2,2,2-trifluoro-1-hydroxyethyl)pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one (Example 87, 127 mg, 0.31 mmol) and TEA (131 μl, 0.94 mmol) in DCM (1.3 mL) and the mixture was stirred for 2 hours. It was diluted with DCM (10 mL), washed with aqueous sodium bicarbonate (5 mL), dried (MgSO4) and concentrated under vacuum to afford the title compound as a brown gum, which was used crude without further purification.

Provenance & Evidence