Potassium Carbonate → HCID 86705400, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 9-(((2S,6R)-2,6-dimethylmorpholino)methyl)pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one (50 mg, 0.16 mmol) and 4-(trifluoromethoxy)benzyl bromide (49 mg, 0.19 mmol) in DMF (2 mL) was added potassium carbonate (44 mg, 0.32 mmol). The resulting mixture was heated at 55° C. overnight. The crude mixture was filtered then purified directly (HPLC, 10-70% ACN-water) to afford the title compound (58 mg, 61%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 1.14 (d, J=6.15 Hz, 6H), 2.63-2.85 (m, 2H), 3.26-3.45 (m, 2H), 3.72-3.86 (m, 2H), 4.40-4.62 (m, 2H), 5.70 (s, 2H), 7.32 (d, J=8.28 Hz, 2H), 7.59 (d, J=8.66 Hz, 2H), 8.69 (s, 1H), 8.84 (s, 1H), 8.89 (br s, 1H). [M+H]=489.2.

Provenance & Evidence