2-(Pyridin-2-yl)but-3-yn-2-ol → HCID 71622137, compound

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Reaction Steps

(2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-hydroxy-3-(pyridin-2-yl)but-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid was prepared by the method in Example 8 from ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate and 2-(pyridin-2-yl)but-3-yn-2-ol. 1H-NMR: 400 MHz, (CD3OD) δ: 8.61 (d, J=6 Hz, 1H), 8.22 (t, J=8 Hz, 1H), 8.05 (d, J=8 Hz, 1H), 7.78 (d, J=8 Hz, 1H), 7.66 (m, 2H), 7.57 (m, 3H), 7.47 (d, J=8 Hz, 1H), 7.35 (s, 1H), 7.30 (d, J=8 Hz, 1H), 5.16 (s, 1H), 2.61 (s, 3H), 1.87 (s, 3H), 0.98 (s, 9H). LCMS-ESI+ (m/z): [M+H]+ calcd for C32H30ClNO4: 528.2. found: 528.1.

Provenance & Evidence