Ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate → HCID 71622139, compound

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Reaction Steps

(2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(2,4-dimethylthiazol-5-yl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid was prepared by the method in Example 8 from ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate and 2-(2,4-dimethylthiazol-5-yl)but-3-yn-2-ol. 1H-NMR: 400 MHz, (CD3OD) δ: 7.78 (d, J=8 Hz, 1H), 7.70 (s, 1H), 7.58 (m, 3H), 7.43 (d, J=8 Hz, 1H), 7.32 (m, 2H), 5.18 (s, 1H), 2.64 (s, 3H), 2.61 (s, 3H), 2.47 (s, 3H), 1.82 (s, 3H), 0.98 (s, 9H). LCMS-ESI+ (m/z): [M+H]+ calcd for C32H32ClNSO4: 562.2. found: 562.1.

Provenance & Evidence