Potassium Carbonate → HCID 89676727, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-2-(7-bromo-3-methyl-1-(trifluoromethylsulfonyloxy)naphthalen-2-yl)-2-tert-butoxyethyl pivalate (825 mg, 1.45 mmol) in 1,4-dioxane (7 mL) was added potassium carbonate (601 mg, 4.35 mmol), trimethylboroxine (220 mg, 1.74 mmol), and PdXPhos catalyst (107 mg, 0.145 mmol). The mixture was heated in a sealed vial in the microwave at 125° C. for 1 h. The mixture was filtered and concentrated in vacuo. The crude material was purified by column chromatography (EtOAc/hexanes) to give the desired product. 1H-NMR: 400 MHz, (CDCl3) δ: 7.84 (s, 1H), 7.66 (d, J=8 Hz, 1H), 7.62 (s, 1H), 7.36 (d, J=8 Hz, 1H), 5.48 (dd, J=9, 3 Hz, 1H), 4.65 (dd, J=12, 9 Hz, 1H), 4.16 (dd, J=12, 3 Hz, 1H), 2.75 (s, 3H), 2.54 (s, 3H), 1.23 (s, 9H) 1.12 (s, 9H).

Provenance & Evidence