2-(1-Chloro-3-methylnaphthalen-2-yl)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)ethyl pivalate → 2-(1-Chloro-3-methylnaphthalen-2-yl)-2-(1,1-difluoro-2-methylpropan-2-yloxy)ethyl pivalate

Participants

Reaction Steps

Compound 2-(1-chloro-3-methylnaphthalen-2-yl)-2-(1,1-difluoro-2-methylpropan-2-yloxy)ethyl pivalate was prepared following the procedure used to prepare 2-(1-chloro-3-methylnaphthalen-2-yl)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)ethyl pivalate of Example 31, except that 2-(1-chloro-3-methylnaphthalen-2-yl)-2-(1,1-difluoro-2-methylpropan-2-yloxy)ethanol was used instead of 2-(1-chloro-3-methylnaphthalen-2-yl)-2-(1,1,1-trifluoro-2-methylpropan-2-yloxy)ethanol. 1H-NMR: 400 MHz, (CDCl3) δ 8.27 (d, J=8.0 Hz, 1H), 7.73 (d, J=8.8 Hz, 1H), 7.57 (s, 1H), 7.56-7.50 (m, 2H), 6.01 (dd, J=8.4, 4.8 Hz, 1H), 5.53 (t, J=56.4 Hz, 1H), 4.47 (dd, J=11.6, 8.4 Hz, 1H), 4.19 (dd, J=11.6, 5.6 Hz, 1H), 2.72 (s, 3H), 1.27 (s, 6H), 1.16 (s, 9H).

Provenance & Evidence