Hydrochloric Acid → 5-(Dimethylamino)-N-(2-oxoethyl)naphthalene-1-sulfonamide

Participants

Reaction Conditions

Reaction Steps

The acetal 11 (287 mg, 850 mop was dissolved in MeOH (1 mL) and coned HCl (0.5 mL) was added to the solution, which was stirred for 1 h at 25° C. The reaction mixture was then evaporated to dryness; the material left was dissolved in CH2Cl2 (10 mL) and the solution was washed with NaHCO3 (2 mL of a saturated aqueous solution). The organic layer was collected and was evaporated under low pressure to give the aldehyde as a light green foam, the total amount of which was used without further purification in the preparation of 12.

Provenance & Evidence