5-(Dimethylamino)-N-(2-oxoethyl)naphthalene-1-sulfonamide → HCID 86710866, compound

HRID 926235Notes

Reaction equation

HRID 926235 reaction equation
C([O:3][CH:4](OCC)[CH2:5][CH2:6][CH2:7][NH:8][S:9]([C:12]1[C:21]2[C:16](=[C:17]([N:22]([CH3:24])[CH3:23])[CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1)(=[O:11])=[O:10])C.O=CCNS(C1C2C(=C(N(C)C)C=CC=2)C=CC=1)(=O)=O.COC(OC)CNS(C1C2C(=C(N(C)C)C=CC=2)C=CC=1)(=O)=O>>[O:3]=[CH:4][CH2:5][CH2:6][CH2:7][NH:8][S:9]([C:12]1[C:21]2[C:16](=[C:17]([N:22]([CH3:24])[CH3:23])[CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1)(=[O:11])=[O:10]

Participants

4

Reactant 3

HCID 187021755-(Dimethylamino)-N-(2-oxoethyl)naphthalene-1-sulfonamideHCID 25172542HCID 25172542, compoundHCID 84426875HCID 84426875, compound

Product 1

HCID 86710866HCID 86710866, compound

Procedure

This aldehyde was prepared from acetal 13 at a scale and under conditions identical to those employed for the preparation N-(2-oxoethyl)-5-(dimethylamino)naphthalene-1-sulfonamide from acetal 11. N-(4-Oxobutyl)-5-(dimethylamino)naphthalene-1-sulfonamide was obtained as a light green foam, the total amount of which was used without further purification in the preparation of 14.

Sources & evidence

ORD record
ord-28ec727996de4514a7cfad18de2032b4
Source dataset
uspto-grants-2016_03
Patent number
US09284343B2

Reaction notes

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