反应详情

温度

-78 °C

methyl 2-(2-acetyl-5-bromo-6-fluoro-1,2-dihydroisoquinolin-1-yl)acetate. To a stirred solution of 5-bromo-6-fluoroisoquinoline (43.9 g, 194 mmol) in DCM (880 mL) acetyl chloride (14.49 mL, 204 mmol) was dropped at RT and the solution was stirred for 60 min. The solution was cooled to −78° C. (yellow suspension) and then a solution of tert-butyl((1-methoxyvinyl)oxy)dimethylsilane (38.4 g, 204 mmol) in DCM (220 mL) was added in one portion. The resulting yellow solution was stirred at −78° C. for 1 h and then allowed to warm to rt overnight. 2N aqueous HCl was added and the reaction mixture was stirred for 10 min. The organic layer was separated and washed with brine (2×). The combined organic layers were dried with sodium sulfate, filtered and the solvent was removed under reduced pressure. The residue was dissolved in diethyl ether, charcoal was added and the mixture was filtrated through a pad of celite. The solvent was evaporated and the crude product was dried under high vacuo overnight to yield the title compound (70.6 g) which was used without further purification. UPLC-MS: MS 342.2/344.2 (M+H+); UPLC rt 1.05 min.

1. stirringThe resulting yellow solution was stirred at −78° C. for 1 h
2. temperatureto warm to rt overnight
3. stirringthe reaction mixture was stirred for 10 min
4. customThe organic layer was separated
5. washwashed with brine (2×)
6. dry with materialThe combined organic layers were dried with sodium sulfate
7. filtrationfiltered
8. customthe solvent was removed under reduced pressure
9. dissolutionThe residue was dissolved in diethyl ether
10. additioncharcoal was added
11. filtrationthe mixture was filtrated through a pad of celite
12. customThe solvent was evaporated
13. dry with materialthe crude product was dried under high vacuo overnight